Cytotoxic necrotizing factors (CNFs) are bacterial exotoxins that have attracted significant attention due to their ability to modify host cell functions by targeting Rho GTPases. These small, ...
The GTPases RHOA, RAC1 and CDC42 control the actin cytoskeleton dynamics that provide the force for cell motility. All three GTPases are activated at the cell front and regulate each other; however, ...
Results of the dose-finding phase of ARST 1321 from the Children's Oncology Group and NRG Oncology: Neoadjuvant chemoradiation or radiation therapy +/- pazopanib in non-rhabdomyosarcoma soft tissue ...
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