A University of Massachusetts Amherst scientist has discovered that a mutation in the misfolding protein that causes Parkinson’s disease offers protection against another fatal neurodegenerative ...

In humans, hundreds of proteins interact in a complex network dubbed the interactome. Those interactions are further complicated when disease-causing mutations are introduced into genes that code for ...

The findings indicate that it may be possible to improve nerve cell health in ALS by modulating the activity of certain ...

A hallmark of Parkinson’s disease is the buildup of Lewy bodies — misfolded clumps of the protein known as alpha-synuclein. Long before Lewy bodies form, alpha-synuclein can interfere with neurons’ ...

Mutations in genes that form the desmosome are the most common cause of the cardiac disease arrhythmogenic cardiomyopathy (ACM), which affects one in 2000 to 5000 people worldwide. Researchers have ...

A research team led by Purdue University’s W. Andy Tao has discovered of a new type of protein modification related to cellular mutation that impairs a crucial enzyme’s ability to help drive energy ...

In a recent study posted to the bioRxiv* preprint server, researchers discovered that the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is susceptible to cleavage at ...

A research team led by Purdue University's W. Andy Tao has discovered a new type of protein modification related to cellular mutation that impairs a crucial enzyme's ability to help drive energy ...

Researchers have discovered that mutations affect protein stability following remarkably simple rules. The discovery has profound implications for accelerating the development of new treatments for ...

The protein is implicated in a wide swath of cancers, but harnessing it for drug R&D is still a major scientific challenge.