Genome-wide approaches are used to discover the RNA-binding targets of the amyotrophic lateral sclerosis (ALS) disease protein FUS/TLS. These studies reveal some shared targets with another ALS-linked ...

Brandeis researchers have made a significant advance in the effort to understand amyotrophic lateral sclerosis (ALS) by successfully reversing the toxicity of a mutated protein in the familial type of ...

NEW YORK, NY, (September 1, 2011) – Although several genes have been linked to amyotrophic lateral sclerosis (ALS), it is still unknown how they cause this progressive neurodegenerative disease. In a ...

WORCESTER, Mass. — Researchers at the University of Massachusetts Medical School (UMMS) have discovered a new gene whose mutations cause familial amyotrophic lateral sclerosis (ALS), a fatal ...

March 5, 2009 — Multiple mutations in the fused in sarcoma/translated in liposarcoma (FUS/TLS) gene were detected in patients with familial amyotrophic lateral sclerosis (ALS), but none were found in ...

Researchers have made a significant advance in the effort to understand amyotrophic lateral sclerosis (ALS) by successfully reversing the toxicity of the mutated protein in the familial type of the ...

Two proteins previously found to contribute to ALS, also known as Lou Gehrig's disease, have divergent roles. But a new study, led by researchers at the Department of Cellular and Molecular Medicine ...

Scientists have uncovered a fresh clue in the mystery that is amyotrophic lateral sclerosis. Unexpectedly, it comes from a gene first implicated in cancer, called fused in sarcoma (FUS). In ...

Specific neurons may degenerate in amyotrophic lateral sclerosis and frontotemporal dementia because they rely heavily on the RNA-binding protein FUS to manage messenger RNAa. This conclusion comes ...

Although several genes have been linked to amyotrophic lateral sclerosis (ALS), it is still unknown how they cause this progressive neurodegenerative disease. In a new study, researchers have ...